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SSA could not be possible without the generous support of Drs. Herbert A. and Betty Lou Lubs and the Science, Society, and the Arts Research Conference Endowment. We are deeply grateful!
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Friday, March 17 • 3:00pm - 4:15pm
Easel 07: Optic nerve regeneration in Xenopus laevis: intact myelin removal and gene expression

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Amphibians are able to regenerate their optic nerve into adulthood, whereas mammals lose this ability before birth. Here, we explore the role of myelin in optic nerve recovery and whether myelin debris hinders regeneration. Specifically, we crush optic nerves and collect them at various time points up to 210 days post-surgery (dps). Using a line of frogs expressing GFP in retinal ganglion cell axons, we establish a timeline of axonal recovery showing full recovery does not occur until day 210. Preliminary data shows intact myelin is absent in nerve segments distal and proximal to the injury by 7 and 11dps, respectively and was not detected by 210dps. Here we also explore protein expression patterns of ?- synuclein and Uchl1, two factors thought to play a role in optic nerve regeneration. These data will help fill a knowledge gap in understanding the basic mechanisms underlying nerve regrowth and regeneration.


Friday March 17, 2017 3:00pm - 4:15pm
Leyburn Library

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