SSA 2017 has ended
SSA could not be possible without the generous support of Drs. Herbert A. and Betty Lou Lubs and the Science, Society, and the Arts Research Conference Endowment. We are deeply grateful!
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Friday, March 17 • 3:00pm - 4:15pm
Easel 20: Access to snacks from weaning onward in female rats causes obesity, insulin insensitivity and sustained leptin resistance in adulthood.

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We developed a female snacking rat model to investigate the mechanisms leading to childhood obesity. We hypothesized that constant access to snacks after weaning causes an early onset of metabolic syndrome. Rats received chow only, healthy snacks, or unhealthy snacks (n=8/group), and all received chow and water. Food intake, snack intake, and body weight were monitored daily. Both snacking groups weighed significantly more than chow-fed rats and had larger abdominal fat pads despite eating fewer calories. Leptin challenges showed that all pubertal rats were resistant to leptin’s ability to reduce food intake, and that snacking rats remained resistant to leptin as adults. A glucose tolerance test determined that snacking rats developed insulin resistance as adults. Thus, constant access to snacks induced early onset of metabolic syndrome. In addition, young rats, and probably humans, are vulnerable to snacks from weaning due to inherent leptin resistance that is sustained into adulthood.

Friday March 17, 2017 3:00pm - 4:15pm
Leyburn Library

Attendees (1)