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SSA could not be possible without the generous support of Drs. Herbert A. and Betty Lou Lubs and the Science, Society, and the Arts Research Conference Endowment. We are deeply grateful!
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Friday, March 17 • 3:00pm - 4:15pm
Easel 16: High-fat high-sugar diet induces polycystic ovary syndrome in a rodent model

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A clear association exists between obesity and PCOS, but the exact nature of this relationship remains unexplained. The primary symptoms of PCOS include hyperandrogenism, anovulation, and polycystic ovaries. Most animal models induce PCOS via androgen treatments, which fail to address underlying causes of the disease and to reproduce key metabolic features such as hyperinsulinemia. Here, we present a novel rodent model of diet-induced obesity that recapitulates metabolic and reproductive phenotypes of human PCOS. Rats fed a high-fat high-sugar (HFHS) diet developed metabolic impairment, polycystic ovaries, and irregular estrous cycling. Elevated testosterone levels predicted high numbers of ovarian cysts. Alterations in steroidogenesis and folliculogenesis gene expression were also found via RNA-sequencing of ovarian tissue. The PCOS-like symptoms induced in these rats may share a similar etiology to PCOS in humans. Therefore, this model offers a unique opportunity to study PCOS at its genesis rather than following the development of disease symptoms.

Friday March 17, 2017 3:00pm - 4:15pm
Leyburn Library